Abstract
Water-soluble antioxidants (1 μM reduced glutathione, 3 μM cysteine, 1 μM ascorbate), in the presence of EDTA, inhibit the adrenalin autoxidation reaction at pH 10.2, whereas their oxidized forms, and also α-tocopherol (40 μM), have no such effect. The inhibiting power of superoxide dismutase is many times greater than that of the substances tested. Adrenochrome formation during free-radical oxidation of adrenalin takes place without the participation of the hydroxyl radical.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
H. P. Misra and I. Fridovich, J. Biol. Chem.,247, 3170 (1972).
D. C. Bord, Proc. Nat. Acad. Sci. (Washington),53, 663 (1965).
D. M. Valerino and J. J. McCormack, Biochem. Pharmacol.,20, 47 (1971).
J. M. McCord and I. Fridovich, J. Biol. Chem.244, 6049 (1969).
J. M. McCord, B. B. Keele, and I. Fridovich, Proc. Nat. Acad. Sci. (Washington),68, 1024 (1972).
S. Green, A. Mazur, and E. Shorr, J. Biol. Chem.,220, 237 (1956).
A. L. Tappel, Lipids and Their Oxidation, Westport (1962).
C. Beauchamp and I. Fridovich, J. Biol. Chem.,245, 4641 (1970).
K. L. Fong, P. B. McCay, J. L. Poyer, et al., J. Biol. Chem.,248, 7792 (1973).
J. Glavind, Acta Chim. Scand.,17, 1635 (1963).
J. D. Crapo and D. F. Tierney, Am. J. Physiol.,226, 1401 (1974).
Rights and permissions
About this article
Cite this article
Brusov, O.S., Gerasimov, A.M. & Panchenko, L.F. Effect of natural inhibitors of free radical reactions on adrenalin autoxidation. Bull Exp Biol Med 81, 39–41 (1976). https://doi.org/10.1007/BF00800160
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800160