Abstract
In experiments on rats and cats a photogenic seizure syndrome was produced by injecting purified tetanus toxin into the lateral geniculate body. Seizures appeared both in response to a photic stimulus and spontaneously. In the period between seizures, flashes evoked photomotor spasms. It is concluded that as a result of disturbance of the mechanisms of inhibition by tetanus toxin a generator of pathologically enhanced excitation arises in the lateral geniculate body and forms the basis of a hyperactive so-called determinant dispatch station, that causes the appearance of the photogenic epilepsy described.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
G. N. Kryzhanovskii, Tetanus [in Russian], Moscow (1966).
G. N. Kryzhanovskii (G. N. Kryzhanovsky), in: Principles of Tetanus, Bern (1967), p. 207.
G. N. Kryzhanovskii, in: General Neurophysiology and Experimental Pathology of the Nervous System [in Russian], Moscow (1970), p. 43.
G. N. Kryzhanovskii, in: Simulation of Diseases [in Russian], Moscow (1973), p. 120.
G. N. Kryzhanovskii, Pat. Fiziol., No. 4, 3 (1973).
G. N. Kryzhanovskii, in: Convergence and Synapses [in Russian], Moscow (1973), p. 109.
G. N. Kryzhanovskii, V. N. Grafova, E. I. Danilova, et al., Byull. Éksperim. Biol. Med., No. 7, 15 (1974).
G. N. Kryzhanovskii, S. I. Igon'kina, V. N. Grafova, et al., Byull. Éksperim. Biol. Med., No. 11, 16 (1974).
G. N. Kryzhanovskii and V. K. Lutsenko, Neirofiziologiya, No. 3, 234 (1975).
G. N. Kryzhanovskii, F. D. Sheikhon, and M. B. Rekhtman, Neirofiziologiya, No. 6, 616 (1975).
L. Mikhailovich and D. Chupich, in: The Simulation of Diseases [in Russian], Moscow (1973), p. 82.
Yu. S. Sverdlov, Neirofiziologiya, No. 1, 25 (1969).
F. D. Sheikhon and M. B. Rekhtman, in: Convergence and Synapses [in Russian], Moscow (1973), p. 109.
V. B. Brooks, D. R. Curtis, and J. C. Eccles, J. Physiol. (London),135, 655 (1957).
W. Burke and A. J. Sefton, J. Physiol. (London),187, 201 (1966).
D. R. Curtis and A. K. Tebecis, Exp. Brain Res.,16, 210 (1972).
D. R. Curtis, D. Felix, and C. G. A. Game, Brain. Res.,51, 358 (1973).
E. Fifková and J. Maršala, in: J. Bureš et al., Electrophysiological Methods in Biological Research, Prague (1967), pp. 653 and 712.
S. Polyak, The Vertebrate Visual System, Chicago (1957), p. 288.
P. D. Wall, A. G. Remond, and R. I. Dobson, Electroenceph. Clin. Neurophysiol.,5, 385 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kryzhanovskii, G.N., Rekhtman, M.B., Konnikov, B.A. et al. Photogenic epilepsy with excitation generator located in the lateral geniculate body (the so-called determinant dispatch station phenomenon). Bull Exp Biol Med 81, 26–29 (1976). https://doi.org/10.1007/BF00800156
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800156