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Investigation of the role of prolonged emotional stress in the genesis of hypercholesteremia and hypertension

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In experiments on freely moving rabbits, exposed to prolonged (for 2 h) interrupted stimulation of negative emotiogenic zones of the hypothalamus through implanted electrodes daily for 4 months, the development of a lasting endogenous hypercholesteremia and of a mild but lasting hypertension was observed. Changes in the cholesterol concentration were greater if stimulation continued in conjunction with daily feeding of the rabbits with small doses of methylthiouracil.

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Literature Cited

  1. P. K. Anokhin, Vestn. Akad. Med. Nauk SSSR, No. 6, 10 (1965).

    Google Scholar 

  2. Yu. N. Bordyushkov and A. Kh. Garkavi, Byull. Éksperim. Biol. Med., No. 6, 61 (1963).

    Google Scholar 

  3. N. I. Grashchenkov, The Hypothalamus and Its Role in Physiology and Pathology [in Russian], Moscow (1965).

  4. A. R. Kosenko and L. K. Finagin, Byull. Éksperim. Biol. Med., No. 4, 34 (1964).

    Google Scholar 

  5. G. F. Lang, Essential Hypertension [in Russian], Moscow (1950), p. 93.

  6. A. L. Myasnikov, Essential Hypertension and Atherosclerosis [in Russian], Moscow (1965).

  7. A. L. Myasnikov, Neuro-Endocrine Factors in Atherosclerosis [in Russian], Moscow (1969).

  8. A. I. Seranova, “The role of nervous and endocrine disturbances in the development of hypercholesteremia and atherosclerosis,” Author's Abstract of Candidate's Dissertation, Leningrad (1970).

  9. K. V. Sudakov, Biol. Zh. Armenii, No. 6, 167 (1972).

    Google Scholar 

  10. N. L. Yastrebtsova and L. V. Simutenko, Dokl. Akad. Nauk SSSR,201, No. 4, 1001 (1971).

    Google Scholar 

  11. C. Gunn, M. Friedman, and S. O. Byers, J. Clin. Invest.,39, 1963 (1960).

    Google Scholar 

  12. C. H. Sawyer et al., J. Comp. Neurol., 101, 801 (1954).

    Google Scholar 

  13. H. Selye, Essays on the Adaptation Syndrome [Russian translation], Moscow (1960).

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Authors
  1. N. L. Yastrebtsova
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  2. L. V. Simutenko
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Additional information

A paper read at the 24th All-Union Conference on Problems in Higher Nervous Activity, Moscow, June (1974).

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Yastrebtsova, N.L., Simutenko, L.V. Investigation of the role of prolonged emotional stress in the genesis of hypercholesteremia and hypertension. Bull Exp Biol Med 81, 23–25 (1976). https://doi.org/10.1007/BF00800155

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  • DOI: https://doi.org/10.1007/BF00800155

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