Abstract
Experiments on isolated strips of the guinea pig taenia coil showed that compound D-600, which blocks calcium channels, depresses the contractile response of depolarized smooth muscle to administration of acetylcholine (5·10−6), histamine (2·10−6), and bradykinin (10−5 g/ml). Besides depressing the effect of biologically active substances, compound D-600 also depresses the “potassium contracture”. It is postulated that the biologically active substances activate the flow of Ca++ ions through the surface membrane but not the discharge of Ca++ from the sarcoplasmic reticulum.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
I. Bilek and U. Peiper, Pflüg, Arch. Ges. Physiol.,343, R-57 (1973).
C. E. Devine, A. V. Somlyo, and A. P. Somlyo, J. Cell Biol.,52, 690 (1972).
M. Endo, N. Tanaka, and Y. Ogawa, Nature,228, 34 (1970).
D. H. L. Evans, H. O. Schild, and S. Thesleff, J. Physiol. (London),143, 474 (1958).
L. E. Ford and R. J. Podolsky, Science,167, 58 (1970).
G. Haeusler, J. Pharmacol. Exp. Ther.,180, 672 (1972).
U. Peiper, L. Griebel, and W. Wende, Pflüg, Arch. Ges. Physiol.,330, 74 (1971).
J. Riemer, F. Dorfler, C. J. Mayer, et al., Pfüg, Arch. Ges. Physiol.,351, 241 (1974).
R. Stämpfli, Experientia,10, 508 (1954).
A. Weber and J. M. Murray, Physiol. Rev.,53, 612 (1973).
Rights and permissions
About this article
Cite this article
Pogadaev, V.I., Timin, E.N. Effect of biologically active substances (acetylcholine, histamine, and bradykinin) on depolarized smooth muscle of the taenia coli. Bull Exp Biol Med 81, 13–15 (1976). https://doi.org/10.1007/BF00800152
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800152