Abstract
The basal secretion of the pancreas and the secretion stimulated by duodenal perfusion were investigated in chronic experiments on dogs. A protein digest stimulated pancreatic enzyme secretion to a greater degree than protein itself. Amobarbital, chlorpromazine, and benactyzine inhibit both basal and stimulated pancreatic secretion. The differential character of pancreatic secretion was disturbed most by chlorpromazine and benactyzine; this is evidence of the essential role of central adrenergic and cholinergic structures in the adaptation of pancreatic secretion to food stimuli.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
S. V. Anichkov, Selective Action of Mediator Substances [in Russian], Leningrad (1974).
V. V. Zakusov, Pharmacology of Central Synapses [in Russian], Moscow (1973).
R. Yu. Il'yuchenok, Neuro-Humoral Mechanisms of the Reticular Formation of the Brain Stem [in Russian], Moscow (1965).
A. S. Sarkisova, Physiology and Pathology of the Organs of Digestion. Proceedings of the 11th All-Union Conference on Physiology and Pathology of Digestion [in Russian], Moscow (1971), pp. 321–323.
G. F. Korot'ko and A. S. Sarkisova, Fiziol. Zh. SSSR, No. 10, 1574 (1973).
G. F. Korot'ko, A. S. Sarkisova, D. G. Rozin, et al., in: Enzyme Secretory Activity of the Digestive Glands and Its Regulation. Proceedings of an All-Union Conference [in Russian], Tashkent (1974), pp. 137–139.
D. G. Rozin, “Abstracts of Proceedings of the 5th Conference of Physiologists of the Republics of Central Asia and Kazakhstan [in Russian], Ashkhabad (1972), p. 252.
D. G. Rozin and M. M. Kadyrova, Abstracts of Proceedings of the 2nd Conference of Physiologists of Uzbekistan [in Russian], Tashkent (1973), pp. 174–175.
L. S. Fomina, Byull. Éksperim. Biol. Med., No. 3, 122 (1963).
L. M. Deschodt, P. Roblerecht, I. Camus, et al., Biochimie,53, 789 (1971).
B. W. Smith and J. H. Roe, J. Biol. Chem.,179, 53 (1949).
K. Wormsley and D. Goldberg, Gut,13, 398 (1972).
Rights and permissions
About this article
Cite this article
Korot'ko, G.F., Rozin, D.G. Effect of some neurotropic drugs on differential enzyme secretion by the pancreas. Bull Exp Biol Med 81, 5–8 (1976). https://doi.org/10.1007/BF00800150
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800150