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Correlation between cytotoxic T lymphocytes and suppressors blocking activation of DNA synthesis in mixed lymphocyte cultures

  • Immunology and Microbiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A parallel study was made of cytotoxic T lymphocytes (CTL) and suppressors induced by immunization in the H-2 system and inhibiting the activation of DNA synthesis in mixed cultures. Unlike the CTL, the suppressors do not adhere specifically to a monolayer of target cells, are not inactivated by treatment with anti-θ serum and complement, and their action is nonspecific: They inhibit the activation of DNA synthesis induced by any stimulator cells whatsoever and also by phytohemagglutinin and concanavalin A. CTL and suppressors are different populations of effector cells which can be separated from each other.

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Authors
  1. E. Ya. Khachikyan
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  2. B. D. Brondz
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  3. G. I. Drizlikh
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  4. S. G. Egorova
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Khachikyan, E.Y., Brondz, B.D., Drizlikh, G.I. et al. Correlation between cytotoxic T lymphocytes and suppressors blocking activation of DNA synthesis in mixed lymphocyte cultures. Bull Exp Biol Med 85, 188–191 (1978). https://doi.org/10.1007/BF00800122

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  • DOI: https://doi.org/10.1007/BF00800122

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