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Bulletin of Experimental Biology and Medicine

, Volume 85, Issue 2, pp 188–191 | Cite as

Correlation between cytotoxic T lymphocytes and suppressors blocking activation of DNA synthesis in mixed lymphocyte cultures

  • E. Ya. Khachikyan
  • B. D. Brondz
  • G. I. Drizlikh
  • S. G. Egorova
Immunology and Microbiology

Abstract

A parallel study was made of cytotoxic T lymphocytes (CTL) and suppressors induced by immunization in the H-2 system and inhibiting the activation of DNA synthesis in mixed cultures. Unlike the CTL, the suppressors do not adhere specifically to a monolayer of target cells, are not inactivated by treatment with anti-θ serum and complement, and their action is nonspecific: They inhibit the activation of DNA synthesis induced by any stimulator cells whatsoever and also by phytohemagglutinin and concanavalin A. CTL and suppressors are different populations of effector cells which can be separated from each other.

Key Words

mixed lymphocyte cultures suppressors activation of DNA synthesis cytotoxic T lymphocytes 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • E. Ya. Khachikyan
  • B. D. Brondz
  • G. I. Drizlikh
  • S. G. Egorova

There are no affiliations available

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