Monatshefte für Chemie / Chemical Monthly

, Volume 113, Issue 4, pp 475–484 | Cite as

Reactions with pyrrolidine-2,4-diones, I. New synthesis of pyrano[2,3-c]pyrrole and pyrrolo[3,4-b]pyridine systems

  • Farid S. G. Soliman
  • Thomas Kappe
Organische Chemie Und Biochemie

Abstract

The synthesis of some substituted 4-hydroxy-2,5,6,7-tetrahydro-pyrano[2,3-c]pyrrole-2,5-diones (5) and 4-hydroxy-1,2,6,7-tetrahydro-5H-pyrrolo[3,4-b]pyridine-2,5-diones (6) by reacting 1,5-diaryl-pyrrolidine-2,4-diones (1) and 1,5-diaryl-1,5-dihydro-4-amino-2H-pyrrol-2-ones (3) with bis-2,4,6-trichlorophenyl malonates (4) is described.

Keywords

Bis-2,4,6-trichlorophenyl malonates 1,5-Diaryl-1,5-dihydro-4-amino-2H-pyrrol-2-ones 1,5-Diarylpyrrolidine-2,4-diones 

Reaktionen mit Pyrrolidin-2,4-dionen, I. Eine neue Synthese von Pyrano[2,3-c]pyrrol- und Pyrrolo[3,4-b]pyridin-Systemen

Zusammenfassung

Die Synthese einiger substituierter 4-Hydroxy-2,5,6,7-tetrahydro-pyrano[2,3-c]pyrrol-2,5-dione (5) und 4-Hydroxy-1,2,6,7-tetrahydro-5H-pyrrolo[3,4-b]pyridin-2,5-dione (6) gelingt durch Reaktion von 1,5-Diaryl-pyrrolidin-2,4-dion (1) bzw. 1,5-diaryl-1,5-dihydro-4-amino-2H-pyrrol-2-on (3) mit Malonsäure-bis-2,4,6-trichlorphenylester (4).

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Farid S. G. Soliman
    • 1
  • Thomas Kappe
    • 2
  1. 1.Department of Pharmaceutical Chemistry, Faculty of PharmacyUniversity of AlexandriaA. R. Egypt
  2. 2.Abteilung für Organische Synthese, Institut für Organische ChemieUniversität GrazGrazÖsterreich

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