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Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 4, pp 1445–1448 | Cite as

Effect of mesencephalic stimulation on responses to nociceptive stimulation of the dental pulp

  • Yu. D. Ignatov
  • A. V. Dmitriev
Physiology

Abstract

Chronic experiments on cats showed that stimulation of certain zones of the mesencephalon reduces or completely suppresses responses to pain caused by stimulation of the dental pulp. Depending on the parameters of brain stimulation the antinociceptive effect was manifested as differential changes in individual motor, autonomic, emotional, and behavioral components of the integral nociceptive response. After-analgesia was found and the dynamics of the return of the various manifestations of pain after cessation of brain stimulation was noted. The possible mechanisms of the antinociceptive effect are discussed.

Key Words

pain mesencephalon analgesia emotional behavior 

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Literature Cited

  1. 1.
    A. V. Val'dman, The Neoropharmacology of Narcotic Analgesics [in Russian], Leningrad (1972).Google Scholar
  2. 2.
    Yu. N. Vasil'ev, “Effect of analgesics and narcotics on presynaptic inhibition of afferents of different modalities at the segmental level and at the level of the nucleus of the trigeminal nerve,” Author's Abstract of Candidate' Dissertation, Leningrad (1975).Google Scholar
  3. 3.
    Yu. D. Ignatov, “The effect of analgesics and narcotics on the neuronal system of the segmental afferent input and its descending regulation”, Author's Abstract of Candidate's Dissertation, Leningrad (1975).Google Scholar
  4. 4.
    Yu. D. Ignatov and Yu. N. Vasil'ev, Proceedings of the 12th All-Union Congress of the Academician I. P. Pavlov Physiological Society [in Russian], Vol. 1, Leningrad (1975), p. 22.Google Scholar
  5. 5.
    M. M. Kozlovskaya and A. V. Val'dman, in: Current Problems in the Pharmacology of the Reticular Formation and Synaptic Transmission [in Russian], Leningrad (1963), pp. 116–164.Google Scholar
  6. 6.
    H. Akil and D. J. Mayer, Brain Res.,44, 692 (1972).Google Scholar
  7. 7.
    S. Balagura and T. Ralph, Brain Res.,60, 369 (1973).Google Scholar
  8. 8.
    J. M. Broockhart, W. K. Livingston, and F. P. Haugen, J. Neurophysiol.,16, 634 (1953).Google Scholar
  9. 9.
    J. C. Liebeskind, G. Guilbaud, J. M. Besson, et al., Brain Res.,50, 441 (1973).Google Scholar
  10. 10.
    D. J. Mayer and J. C. Liebeskind, Brain Res.,68, 73 (1974).Google Scholar
  11. 11.
    R. Melzack and D. R. Melinkoff, Exp. Neurol.,43, 369 (1974).Google Scholar
  12. 12.
    J. L. Oliveras, A. Woda, G. Guilbaud, et al., C. R. Acad. Sci. (Paris),276, 2705 (1973).Google Scholar
  13. 13.
    D. V. Reynolds, Science164, 444 (1969).Google Scholar
  14. 14.
    D. J. Scott and G. G. Stewart, Oral Surg.,20, 784 (1965).Google Scholar
  15. 15.
    R. S. Snider and W. T. Niemer, A. Stereotaxic Atlas of the Cat Brain, Chicago (1961).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Yu. D. Ignatov
  • A. V. Dmitriev

There are no affiliations available

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