Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 4, pp 1445–1448 | Cite as

Effect of mesencephalic stimulation on responses to nociceptive stimulation of the dental pulp

  • Yu. D. Ignatov
  • A. V. Dmitriev


Chronic experiments on cats showed that stimulation of certain zones of the mesencephalon reduces or completely suppresses responses to pain caused by stimulation of the dental pulp. Depending on the parameters of brain stimulation the antinociceptive effect was manifested as differential changes in individual motor, autonomic, emotional, and behavioral components of the integral nociceptive response. After-analgesia was found and the dynamics of the return of the various manifestations of pain after cessation of brain stimulation was noted. The possible mechanisms of the antinociceptive effect are discussed.

Key Words

pain mesencephalon analgesia emotional behavior 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Yu. D. Ignatov
  • A. V. Dmitriev

There are no affiliations available

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