Specific and nonspecific biochemical phases of immunogenesis

  • M. I. Ravich-Shcherbo
  • L. G. Prokopenko
Microbiology and Immunity


Studies of the antibody synthesis in various antigens and of the production of nonspecific γ-globulins in various ratios of immunization periods demonstrate that the inductive phase of antibody formation occurs in two stages: the first — nonspecific one — consisted in the proliferation of mesenchymal cells, resulting in an intensified production of γ-globulins; the second stage of immunochemical reconstruction (inductive phase proper) consisted in the modification (under the effect of antigen) of the proteosynthesis mechanisms, due to which antibody formation takes place.


Public Health Mesenchymal Cell Inductive Phase Antibody Formation Antibody Synthesis 
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Copyright information

© Consultants Bureau 1964

Authors and Affiliations

  • M. I. Ravich-Shcherbo
    • 1
  • L. G. Prokopenko
    • 1
  1. 1.Department of Biological ChemistryKursk Medical InstituteKurskUSSR

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