The effect of disturbance of acetylcholine metabolism on cathode threshold parabiosis curves and on the functional stability of the nerve trunk

  • V. I. Alatyrev
  • L. N. Zefirov


In disturbance of acetylcholine synthesis caused by preliminary excision of the pancreas or by treating the nerve with 2-methylnaphthoquinone (a cholinesterase inhibitor) there is an accelerated development of nerve parabiosis under the effect of direct current cathode. The minimal intensity of direct current, maintaining a nonconductivity state, decreases in these conditions more rapidly and reaches lower values than in cases of control preparations. As a result of this the curve of threshold cathodic parabiosis proves to be displaced to the axis of ordinates and to the axis of abscissae. The occuring changes testify to a reduction of the nerve resistance to the action of alteration and decrease of restorative, compensatory processes.


Public Health Acetylcholine Direct Current Cholinesterase Minimal Intensity 
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Literature Cited

  1. 1.
    L. L. Vasil'ev. The Importance of N. E. Vvedenskii's Teaching in Neuropathology [in Russian]. Leningrad, 1953.Google Scholar
  2. 2.
    Z. S. Dontsova, Nauchn. dokl. vyssh. shkoly. Biol. nauki, 3, 81 (1960).Google Scholar
  3. 3.
    O. V. Zeidlits, Byull. éksper. biol.7, 6, 514 (1939);9, 6, 405 (1940).Google Scholar
  4. 4.
    L. N. Zefirov and A. V. Kibyakov, Fiziol. zh. SSSR, 2, 183 (1954).Google Scholar
  5. 5.
    L. N. Zefirov and O. S. Kochnev, Byull. éksper. biol. 4, 3 (1958).Google Scholar
  6. 6.
    L. N. Zefirov and O. S. Kochnev. In the book: The Physiological Role of Mediators [in Russian], p. 19, Kazan', 1959.Google Scholar
  7. 7.
    L. N. Zefirov and L. V. Tukhvatullina, Byull. éksper. biol., 4, 71 (1960).Google Scholar
  8. 8.
    A. A. Zubkov, Byull. éksper. biol.6, 5, 595 (1938).Google Scholar
  9. 9.
    D. G. Kvasov, Fiziol. zh. SSSR34, 4, 471 (1948).Google Scholar
  10. 10.
    A. V. Kibyakov and A. A. Uzbekov, Byull. éksper. biol. 3, 202 (1950).Google Scholar
  11. 11.
    D. A. Lapitskii. The Functional Analysis of Certain Pathological Processes [in Russian]. Leningrad, 1948.Google Scholar
  12. 12.
    P. Nordquist, Acta pharmacol. (Kbh.), 1954, v. 10, p. 46.Google Scholar
  13. 13.
    C. Torda and H. G. Wolff, Proc. Soc. exp. Biol. (N. Y.), 1944, v. 57, p. 236.Google Scholar
  14. 14.
    Idem, Science, 1946, v. 103, p. 645.Google Scholar

Copyright information

© Consultants Bureau 1964

Authors and Affiliations

  • V. I. Alatyrev
    • 1
  • L. N. Zefirov
    • 1
  1. 1.Department of Normal PhysiologyKazan' Medical InstituteKazanUSSR

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