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Effect of chronic pyrogenal stress on the mitotic regime and number of DNA-synthesizing cells in the corneal and lingual epithelium of albino rats

  • Experimental Biology
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Abstract

The effect of prolonged stress on the mitotic regime and number of DNA-synthesizing cells in the corneal and lingual epithelium was studied in response to pyrogenal. Injection of pyrogenal for 5 days caused a decrease of 41% in the number of mitoses in the corneal and lingual epithelium. The decrease in the number of dividing cells did not correlate with changes in the rate of mitosis. The number of pathological mitoses in the corneal epithelium of intact rats remained unchanged during stress. The index of labeled nuclei in the corneal and lingual epithelium of the control rats was 12.6 and 10.8 respectively, which did not differ significantly from their values in the experimental animals (12.2 and 12.2).

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Literature Cited

  1. I. A. Alov, The Cytophysiology and Pathology of Mitosis [in Russian], Moscow (1972).

  2. O. Sh. Dzheksenbaev and N. A. Ozeretskovskii, in: Symposium on the Results of the Experimental Study and Clinical Use of Pyrogenal. Abstracts of Proceedings [in Russian], Moscow (1964), p. 6.

  3. V. D. Lindenbraten, Probl. Éndokrinol., No. 3, 74 (1967).

    Google Scholar 

  4. Yu. A. Pankov and N. Ya. Usvaitova, in: Methods of Clinical Biochemistry of Hormones and Mediators [in Russian], Part 1, Moscow (1973), p. 66.

  5. N. B. Simon, S. S. Timoshin, and S. A. Alekseenko, Byull. Éksp. Biol. Med., No. 11, 1371 (1976).

    Google Scholar 

  6. S. S. Timoshin, Vest. Dermatol., No. 2, 45 (1969).

    Google Scholar 

  7. S. S. Timoshin, Vest. Dermatol., No. 1, 68 (1971).

    Google Scholar 

  8. S. S. Timoshin, “The effect of pyrogenal on mitotic activity of some types of epithelium,” Author's Abstract of Candidate's Dissertation, Makhachkala (1971).

  9. S. S. Timoshin and S. A. Alekseenko, Byull. Éksp. Biol. Med., No. 1, 74 (1974).

    Google Scholar 

  10. S. Gelfant and G. Candelas, J. Invest. Derm.,59, 7 (1972).

    Google Scholar 

  11. S. Lifschitz, in: Laboratory Methods of Clinical Investigation [in Russian], Warsaw (1965), p. 323.

  12. References 13 and 14 not given in Russian original — Consultants Bureau. E. Van Scott and T. W. Ekel, Arch. Derm.,88, 373 (1963).

    Google Scholar 

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Authors
  1. S. S. Timoshin
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  2. N. B. Murzina
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Timoshin, S.S., Murzina, N.B. Effect of chronic pyrogenal stress on the mitotic regime and number of DNA-synthesizing cells in the corneal and lingual epithelium of albino rats. Bull Exp Biol Med 86, 1112–1114 (1978). https://doi.org/10.1007/BF00799608

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  • DOI: https://doi.org/10.1007/BF00799608

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