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Insulin-forming activity of monolayer cultures of bovine fetal pancreatic islet cells

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

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Abstract

The insulin concentration in the growth medium of primary monolayer cultures of bovine fetal pancreatic islet cells grown in the presence of a normal and increased (300 mg%) glucose content, was determined by a radioimmunologic method. A high glucose concentration led to increased secretion of insulin. The results of the cytological study showed definite correlation between mitotic activity of the cells of the culture and the intensity of insulin secretion into the medium.

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Literature Cited

  1. R. A. Babikova, V. N. Blyumkin, B. I. Shal'nev, et al., Byull. Éksp. Biol. Med., No. 3, 350 (1977).

    Google Scholar 

  2. V. N. Blyumkin, B. I. Shal'nev, and R. A. Babikova, in: Problems in Transplantology and Artificial Organs [in Russian], Moscow (1977), pp. 67–70.

  3. W. L. Chick, A. A. Like, and V. Lauris, Endocrinology,96, 637 (1975).

    Google Scholar 

  4. J. Hilwig, S. Schuster, W. Heptner, et al., Z. Zellforsch.,90, 333 (1968).

    Google Scholar 

  5. A. E. Lambert, B. Blondel, Y. Kanazawa et al., Endocrinology,90, 239 (1972).

    Google Scholar 

  6. S. Moskalewski, Gen. Comp. Endocrinol.,5, 342 (1965).

    Google Scholar 

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Authors
  1. V. P. Fedotov
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  2. V. N. Blyumkin
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  3. R. A. Babikova
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  4. N. V. Sadovnikova
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  5. V. V. Abramova
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  6. B. I. Shal'nev
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Fedotov, V.P., Blyumkin, V.N., Babikova, R.A. et al. Insulin-forming activity of monolayer cultures of bovine fetal pancreatic islet cells. Bull Exp Biol Med 86, 1099–1101 (1978). https://doi.org/10.1007/BF00799604

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  • DOI: https://doi.org/10.1007/BF00799604

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