Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 2, pp 1071–1072 | Cite as

Effect of route of antitoxin administration on efficacy of treatment of experimental tetanus

  • Ya. I. Aleksevich
Microbiology and Immunology


The efficacy of treatment with Diaform-3 antitoxin, given by either intracisternal or intralumbar injection in a dose of 400 i.u./kg, was compared in experiments on 100 rabbits with ascending, hematogenous, and cerebral tetanus caused by injection of 1 c.l.d. of tetanus toxin. Intracisternal injection of the antitoxin was found to be three times more effective than intralumbar (the proportion of animals cured was 31.4 and 10.2% respectively). The latter was effective only in animals with ascending tetanus, evidently because the portal of entry of the toxin into the CNS was along the peripheral nerves of the hind limbs.

Key Words

tetanus antitoxin — routes of administration 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Ya. I. Aleksevich

There are no affiliations available

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