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Chronobiological aspect of the mechanism of lithium salts action in experimental alcoholism

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After consumption of a 5% solution of ethanol for two months the diurnal rhythm of histophysiological activity of the rat pineal gland was found to be disorganized. A course of lithium chloride injections in doses corresponding to those used clinically reversed these changes and prevented their development if given during the two months' consumption of ethanol. This effect of lithium correlated with the suppression of preference for ethanol observed under these experimental conditions, or with the prevention of its development. The possible link between this property of lithium salts to reverse chronobiological disturbances of pineal activity and their clinical efficacy in alcoholism and other affective disturbances with a periodic course is discussed.

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Authors
  1. A. N. Yavorskii
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  2. B. I. Lyubimov
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Yavorskii, A.N., Lyubimov, B.I. Chronobiological aspect of the mechanism of lithium salts action in experimental alcoholism. Bull Exp Biol Med 86, 1051–1053 (1978). https://doi.org/10.1007/BF00799588

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  • DOI: https://doi.org/10.1007/BF00799588

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