Abstract
On treatment of submitochondrial particles (SMP) from bovine heart with the platinum complex K[C2H4PtCl3] (Zeize's salt) a menadione-dependent shunt is formed in them, and is manifested as stimulation of the oxygen uptake by menadione when electron transport is blocked by rotenone. The effect is observed only when NADH and not succinate is used as substrate. Menadione-dependent respiration induced by Zeize's salt is sensitive to dicoumarin but is not inhibited by antimycin or cyanide, which distinguishes it from the menadione-reductase shunt in intact mitochondria.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Yu. Sh. Moshkovskii and L. M. Raikhman, Biofizika, No. 4, 631 (1974).
L. M. Raikhman and L. A. Blyumenfel'd, Biokhimiya, No. 6, 1127 (1966).
V. P. Skulachev, Accumulation of Energy in the Cell [in Russian], Moscow (1969).
L. V. Tat'yanenko, L. M. Raikhman, T. A. Toshcheva, et al., Biokhimiya, No. 8, 1236 (1976).
L. Ernster, G. Dallner, and C. F. Azzone, J. Biol. Chem.,238, 1124 (1963).
M. Hansen and A. L. Smith, Biochim. Biophys. Acta,81, 214 (1964).
Rights and permissions
About this article
Cite this article
Kolesova, G.M., Raikhman, L.M., Zakharova, I.A. et al. Induction of a menadione-dependent respiratory shunt by a platinum complex. Bull Exp Biol Med 86, 1017–1019 (1978). https://doi.org/10.1007/BF00799577
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00799577