Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 2, pp 1007–1010 | Cite as

Erythropoietin and erythropoiesis inhibitor in normal and hypoxic neonates

  • V. I. Gudim
  • A. Michell
  • P. Scigalla
  • V. S. Ivanova
  • J. Gross


Erythropoietin and erythropoiesis inhibitor were studied in 22 healthy neonates and 31 neonates with transposition of the major arteries (TMA) using polycythemic mice as the model. Erythropoietin could not be detected in the plasma or urine of healthy neonates aged 5–7 days, but erythropoiesis inhibitor was found during this period. The erythropoietin level was raised in neonates with TMA until the 14th day, and lowered from the 14th to the 56th day. In concentrates of the 24-hourly urine sample from neonates with hypoxia aged 3–4 weeks erythropoiesis inhibitor also was found. The role of erythropoiesis inhibitor as a physiological regulator appearing in the blood of healthy neonates and neonates with hypoxia in the normalization of erythropoiesis during the first weeks after birth is discussed.

Key Words

erythropoietin erythropoiesis inhibitor hypoxic neonates (neonates with transposition of the major arteries) polycythemia 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • V. I. Gudim
  • A. Michell
  • P. Scigalla
  • V. S. Ivanova
  • J. Gross

There are no affiliations available

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