Abstract
An increase in the heat production of a single contraction of the isolated rat diaphragm under the influence of 2,4-dinitrophenol (DNP) was demonstrated by a highly sensitive thermometric method (1·10−5 °C/mm). The action of low concentrations of DNP caused no visible changes in the resting muscle but changes were clearly visible during contraction. After exposure to DNP and during contraction of the muscle of equal force, its heat production was increased by almost 50%. This fact confirms the hypothesis that uncoupling of oxidation and phosphorylation in the respiratory chain of the muscle cell plays the leading role in the mechanism of increased heat production of muscular contractions in animals after adaptation to cold.
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Pchelenko, L.D. Increase in heat production of muscular contraction caused by 2,4-dinitrophenol. Bull Exp Biol Med 86, 985–987 (1978). https://doi.org/10.1007/BF00799568
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DOI: https://doi.org/10.1007/BF00799568