Comparison of hemolglobin dissolved in plasma and contained in red cells for maintaining the circulation and respiration
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The basic circulatory and respiratory indices were compared in two series of cats. In the animals of series I the blood was completely replaced by an 8% solution of human hemoglobin (Hb), purified from stroma and procoagulant activity, whereas in the animals of series II the blood was diluted with dextran to an Hb concentration of 8 g%. The solution readily became saturated in the lungs and gave up its oxygen in the tissues, but did so much less readily than Hb contained in red cells. Dissolved Hb did not completely meet the oxygen demand of the body, and the animals developed hypoxia. Moderate anemic hypoxia caused by dilution of the blood with dextran was easily compensated. An Hb solution can be regarded as the basis or first stage in the creation of a blood substitute and oxygen carrier.
Key Wordshemoglobin blood substitutes hypoxia
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