Abstract
The effect of growth hormone on the DNA content in lymphocyte nuclei in the thymus, spleen, and lymph nodes was investigated cytophotometrically. In hypophysectomized rats growth hormone was shown to increase the DNA content in nuclei of medium lymphocytes of these organs but did not change its content in small lymphocytes. Lymphocytes of the thymus were most sensitive to the action of growth hormone. The DNA content in the nuclei of these cells increased as early as 1 h after injection of the hormone and reached its maximum after 4 h. Other hormones with anabolic action (insulin, thyroxine, testosterone) caused no increase in DNA in the thymocyte nuclei during this period. It is concluded that growth hormone has high affinity for cells of the lymphoid organs and, in particular, for thymocytes (medium lymphocytes of the thymus).
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Fedotov, V.P., Finnik, V.P. & Aleshina, L.V. Specificity of the effect of growth hormone on the DNA content in lymphocyte nuclei of hypophysectomized rats. Bull Exp Biol Med 82, 1411–1413 (1976). https://doi.org/10.1007/BF00799494
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DOI: https://doi.org/10.1007/BF00799494