Abstract
Thyroxine, in a dose of 10 μg/ml, differed in its effect on the various periods of the mitotic cycle of HeLa cell cultures in the logarithmic and stationary phases of growth. In the logarithmic phase thyroxine shortened only the G2min-period (by 2 h) and had no effect on the duration of the other phases of the mitotic cycle. In a stationary culture thyroxine shortened the total duration of the mitotic cycle by 3–7 h, mainly on account of a decrease in the time spent in the G1+1/2M periods (by 4–8 h) and, to some extent, the G2min-period (by 1 h). It is concluded that the hormone stimulates the entry of the cells into the mitotic cycle from the G0-period in the stationary culture.
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Ivchenko, T.N., Romanov, Y.A. Action of thyroxine on mitotic cycle of cell cultures. Bull Exp Biol Med 82, 1405–1407 (1976). https://doi.org/10.1007/BF00799492
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DOI: https://doi.org/10.1007/BF00799492