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The use of cross-reacting microbial antigens to abolish tolerance produced to transplantation mouse antigen

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Immunization of CC57BR mice tolerant toCandida albicans antigens and to related C3H mouse transplantation antigens and to group A (type I)Streptococcus containing antigens cross-reacting with the donor's tissues partially abolished tolerance to C3H mouse alloantigens. This was manifested as shortening of the survival of skin allografts and an increase in the rate of elimination of51Cr-labeled donor's lymphocytes from the lymph nodes and spleen. The immune response toC. albicans antigens was not restored.

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Ogurtsov, R.P. The use of cross-reacting microbial antigens to abolish tolerance produced to transplantation mouse antigen. Bull Exp Biol Med 82, 1382–1384 (1976). https://doi.org/10.1007/BF00799484

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  • DOI: https://doi.org/10.1007/BF00799484

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