Abstract
Globulin-producing cells, consisting of lymphocytes, intermediate transformed cells, blast cells, and plasma-like cells were discovered by Coons' method in human peripheral blood lymphocyte cultures after stimulation by staphylococcal filtrate and phytohemagglutinin (PHA). Analysis of the dynamics of appearance of these cells suggests that they arise from a special subpopulation of B lymphocytes: immunological memory cells. Some globulin-producing cells arise from precursors without division, whereas for others differentiation is combined with proliferation.
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Lebedev, K.A., Samsygin, S.A., Nechaeva, T.A. et al. Globulin-producing cells in cultures of blast-transformed lymphocytes in vitro. Bull Exp Biol Med 82, 1367–1370 (1976). https://doi.org/10.1007/BF00799478
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DOI: https://doi.org/10.1007/BF00799478