Abstract
After denervation and in avitaminosis E the cyclic AMP level, falls in rabbit muscle tissue but activity of cyclic AMP phosphodiesterase rises. In experiments in vitro cyclic AMP, in a concentration of 10−4M inhibits the liberation of acid phosphatase from the lysosomerich fraction isolated from the muscles of rabbits with avitaminosis E. In muscular dystrophy, the increase in acid hydrolase activity in the skeletal muscle may thus be due to liberation of enzymes from the lysosomes, as a result of labilization of their membranes through a fall in cyclic AMP concentration.
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Kozlov, A.V., Korovkin, B.F. Possible role of cyclic amp in regulation of muscle tissue acid hydrolase activity in avitaminosis E and denervation. Bull Exp Biol Med 82, 1335–1336 (1976). https://doi.org/10.1007/BF00799467
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DOI: https://doi.org/10.1007/BF00799467