Abstract
The effect of endogenous carcinogenic substances (3-hydroxyanthranilic and parahydroxyphenyllactic acids) and their noncarcinogenic analogs (anthranilic and phenyllactic acids) on tyrosine aminotransferase activity was compared in rat liver. The carcinogenic metabolites were found to have the property of sharply inducing activity of the enzyme. This phenomenon and existing data on the role of the increase in tyrosine aminotransferase and tryptophan oxygenase activity in tyrosine and tryptophan catabolism in the direction of the possible formation of carcinogenic metabolites suggest that there is a “chain reaction” of accumulation of endogenous carcinogens in the body.
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Raushenbakh, M.O., Levchuk, A.A. Induction of tyrosine aminotransferase by carcinogenic metabolites of tryptophan and tyrosine. Bull Exp Biol Med 82, 1330–1332 (1976). https://doi.org/10.1007/BF00799465
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DOI: https://doi.org/10.1007/BF00799465