Abstract
Incorporation of leucine-14C and methionine-35S into tissue homogenates and protein isolated from various parts of the brain of rats exposed to acute hypoxia in the antenatal period was investigated. Besides active incorporation of amino acids into proteins in other parts of the brain, inhibition of protein synthesis also was observed in certain structures in the experimental animals, especially in the hippocampus. Changes in the uptake of labeled amino acids by the tissue homogenates did not correspond to the level of their incorporation into protein in the individual brain structures. The experimental results points to a disturbance of the intensity of protein metabolism and of the function of the blood-brain barrier in late ontogeny in rats exposed to intrauterine hypoxia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. I. Bodyazhina, Akush. Ginekol. No. 3, 3 (1953).
O. S. Vinogradova, The Hippocampus and Memory [in Russian], Moscow (1974).
L. G. Voronin and T. P. Semenova, Zh. Vyssh. Nerv. Deyat., No. 4, 574 (1968).
A. P. Dyban, “Outlines of human pathological embryology”, Doctoral Dissertation, Leningrad (1959).
A. L. Zabludovskii, M. Ya. Maizelis, and R. I. Kruglikov, Byull. Éksp. Biol. Med., No. 8, 928 (1976).
Z. N. Kiseleva, Byull. Éksp. Biol. Med., No. 4, 115 (1960).
Z. N. Kiseleva and T. B. Mladovskaya, in: Scientific Information of the Department of Scientific and Medical Information, Academy of Medical Sciences of the USSR [in Russian], No. 1, Moscow (1961). pp. 43–44.
B. N. Klosovskii and E. P. Kosmarskaya, Vestn. Akad. Med. Nauk SSSR, No. 1, 18 (1969).
M. Ya. Maizelis, The Blood-Brain Barrier and its Regulation [in Russian], Moscow (1973).
A. S. Savchishina, in: Advances in Diagnosis, Treatment, and Prophylaxis of the More Important Diseases [in Russian], Rostov-on-Don (1974), pp. 57–58.
G. Bray, Analyt. Biochem.,1, 279 (1960).
J. Davis and W. Himwich, in: Ontogenesis of the Brain, Vol. 2, prague (1974), pp. 101–109.
L. Jilek, S. Trojan, E. Travnickova, et al., in: Ontogenesis of the Brain, Vol. 2, Prague (1974), pp. 137–156.
D. P. Kimble and K. H. Pribram, Science,139, 824 (1963).
W. Windle, Neurological, and Psychological, Deficits of Asphyxia Neonatorum, Thomas, Springfield (1958).
Rights and permissions
About this article
Cite this article
Maizelis, M.Y., Zabludovskii, A.L. Effect of acute hypoxia in the antenatal period on uptake of labeled amino acids into rat brain proteins and tissue homogenates. Bull Exp Biol Med 82, 1327–1329 (1976). https://doi.org/10.1007/BF00799464
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00799464