Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 3, pp 1314–1317 | Cite as

Membrane Na, K-ATPase and acetylcholinesterase activity of the brain and spinal cord of rats during seizures

  • G. N. Kryzhanovskii
  • A. M. Golenda
  • V. V. Shevtsov
  • R. N. Glebov
Biochemistry and Biophysics


Activity of ATPases and acetylcholinesterase (ACE) in the fractions of unpurified mitochondria (UMF) and microsomes from the cortex of the brain and spinal cord of rats in the clonic phase of electrically induced seizures and in the postconvulsive period (5 min after the end of the seizures) was investigated. Inhibition of Na, K-ATPase activity in UMF of the brain in the clonic phase of convulsions and increased activity of this enzyme in all fractions of tissues studied in the postconvulsive period were found. Activity of Ca-ATPase in brain UMF increased during seizures but fell in the postconvulsive period, whereas activity of Mg-ATPase was unchanged. ACE activity as a rule increased during seizures; in the postconvulsive period a further increase in ACE activity was observed in the brain tissue but the activation effect was reduced in the spinal cord tissue. The possibility of structural changes in the excitable membranes of neurons during seizure activity is discussed.

Key Words

ATPase acetylcholinesterase brain and spinal cord seizures structural changes in membranes 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • G. N. Kryzhanovskii
    • 1
  • A. M. Golenda
  • V. V. Shevtsov
  • R. N. Glebov
  1. 1.Academy of Medical Sciences of the USSRUSSR

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