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Serum humoral factors causing the altered physiological state of the peripheral blood lymphocytes in schizophrenia

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Statistically significant correlation was found between the relative percentage of cells responding to stimulation by phytohemagglutinin (PHA) by DNA synthesis in cultures of lymphocytes from patients with schizophrenia and also in the percentage of lymphocytes no longer responding to PHA stimulation by DNA synthesis in cultures of white blood cells from healthy donors as a result of the cultivation of those cells in medium containing 20% blood serum from patients with schizophrenia. Similar correlation was found between the relative percentage of adhesive lumphocytes in cultures of white blood cells from patients with schizophrenia and in the percentage of adhesive lymphocytes in cultures of white blood cells from healthy donors as a result of their cultivation in medium containing 20% blood serum of schizophrenic patients. The results confirm the hypothesis that the altered physiological state of the peripheral blood lymphocytes of patients with schizophrenia is due to factors present in the blood serum of such patients.

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Authors
  1. R. R. Lideman
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  2. N. G. Babayan
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Lideman, R.R., Babayan, N.G. Serum humoral factors causing the altered physiological state of the peripheral blood lymphocytes in schizophrenia. Bull Exp Biol Med 82, 1309–1311 (1976). https://doi.org/10.1007/BF00799458

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  • DOI: https://doi.org/10.1007/BF00799458

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