Abstract
A decrease in the rate of corticosterone synthesis by adrenal slices and a decrease in cytoplasmic dehydrogenase activity of the adrenal cells were observed in male rats 48 h after partial hepatectomy, when the level of steroid metabolism in the liver was low, compared with the situation in animals undergoing a mock operation. The changes found are the result of depression of central mechanisms of stress as a result of the lowered steroid metabolism. Intraperitoneal injection of CCl4 into rats in a dose of 0.1 ml/100 g body weight at these same times led to a marked increase in steroid production in the adrenal tissue and activation of NAD-dependent cytoplasmic dehydrogenases. The role of toxic damage to the glands in the changes in the functional state of the adrenocortical cells is discussed.
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Yakobson, G.S., Shershnev, V.N., Gizatulin, Z.Y. et al. Glucocorticoid function and cytoplasmic dehydrogenase activity of the adrenals following mechanical and toxic injury to the liver. Bull Exp Biol Med 82, 1301–1304 (1976). https://doi.org/10.1007/BF00799455
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DOI: https://doi.org/10.1007/BF00799455