Abstract
It is shown that the rebreathing method can be used to study the cardiac output even when the ventilation does not correlate with the pulmonary blood flow. pCO2 was measured in mixed venous blood by equilibrating it with pCO2 in the alveolar air by the rebreathing method. A gas mixture with a CO2 concentration close to that in venous blood was produced by the subject himself during rebreathing into a bag with a capacity of 2–3 liters, filled with oxygen. Irregularity of distribution of ventilation relative to blood flow was judged from the shape of the CO2 concentration versus time curve. If signs of irregularity are present, it is impossible to make petCO2 equal to pACO2 and for that reason pCO2 of arterialized blood was determined. By means of this correction it is possible to determine the cardiac output of patients with cardiac and pulmonary diseases. The possibility of using standard nomograms for calculating the CO2 concentration in the arterial and venous blood in the presence of appreciable disturbances of the acid-base balance is discussed.
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Vinitskaya, R.S., Koganova, N.A. Some aspects of determination of the cardiac output by the rebreathing method. Bull Exp Biol Med 83, 274–277 (1977). https://doi.org/10.1007/BF00799445
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DOI: https://doi.org/10.1007/BF00799445