Abstract
Toxic edema of the lungs during influenza develops 3 h after infection of mice with concentrated influenza viruses adapted to lung tissue. The toxic action of the viruses is manifested by filling of the alveoli with a liquid exudate, by the development of stasis in the pulmonary vessels, by eosinophilic necrosis of the epithelium of the bronchioles, and also by destruction of cells of the cortical layer of the thymus. The model thus developed can aid with the understanding of fulminating forms of influenzal infection in man terminating in death.
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Parusov, V.N., Zhunko, V.V. Experimental toxic pulmonary edema in albino mice with influenza. Bull Exp Biol Med 83, 271–273 (1977). https://doi.org/10.1007/BF00799444
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DOI: https://doi.org/10.1007/BF00799444