Abstract
The harmful action of fractionated x-ray irradiation (12 rad daily, total dose 250, 500, 750, 1000, or 1500 rad) on hematopoiesis was studied in guinea pigs. The dynamics of the changes in erythro- and myelopoiesis after irradiation was phasic in character. In the first phase activation of proliferative processes was manifested as an increase in the mitotic index, shortening of the mitotic cycle of cells of the erythroid and myeloid series, and their more rapid differentiation, so that as a result a sufficient number of cells entered the blood stream and maintained a near-normal number of erythrocytes and leukocytes in peripheral blood. In the second phase weakening of proliferative processes was observed in the bone marrow, the mitotic index was reduced, the duration of the mitotic cycle was increased, and differentiation of cells of the erythroid and myeloid series was slowed, with the development of anemia and leukopenia in the peripheral blood.
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Teterina, V.I. Kinetics of bone marrow cells during fractionated x-ray irradiation. Bull Exp Biol Med 83, 249–252 (1977). https://doi.org/10.1007/BF00799438
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DOI: https://doi.org/10.1007/BF00799438