Adaptation to the action of some teratogens following administration of pesticides during pregnancy

Abstract

In experiments on female Wistar rats the effect of the pesticides DDT and γ-BHC, administered from the beginning of pregnancy, on the intensity of the teratogenic action of sodium salicylate (SS) and of benlate, a pesticide of the carbonate group, was studied. The compounds were given on the 10th and 12th days of pregnancy respectively. Preliminary administration of the pesticides was shown to weaken the teratogenic and embryotoxic action of benlate, given in a dose of 250 mg/kg, and of SS in a dose of 400 mg/kg. Under the influence of SS in a dose of 600 mg/kg preliminary injection of the pesticides reduced the postimplantation mortality of the embryos, but the number of fetuses with developmental anomalies was the same as after the isolated action of SS in the same dose.