Abstract
A fragment of bone marrow transplanted beneath the capsule of the kidney creates a focus of ectopic hematopoiesis the size of which, measured according to the number of hematopoietic cells, is proportional to the size of the implant. In irradiated recipients the focus was 1.5–2.5 times larger than in intact recipients. Cells creating a focus of heterotopic hematopoiesis in intact and irradiated recipients differed in their radiosensitivity: their D0 values were about 160 and 350 rad, respectively. In this connection it is postulated that two populations of precursor cells participate in the creation of the focus. Their possible relations with predetermined and inducible osteogenic precursor cells are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
W. Chamberlin, J. Barone, A. Kedo, et al., Blood,44, 385 (1974).
A. J. Friedenstein (A. Ya. Fridenshtein) et al., Transplantation,6, 230 (1968).
A. J. Friedenstein (A. Ya. Fridenshtein), in: Symposium on Hard Tissue Growth, Repair and Remineralization, Amsterdam (1973), pp. 169–182.
J. E. Till and E. A. McCulloch, Radiat. Res.14, 213 (1961).
Rights and permissions
About this article
Cite this article
Chertkov, I.L., Gurevich, O.A. Two populations of bone marrow cells creating an ectopic hematopoietic focus. Bull Exp Biol Med 83, 218–221 (1977). https://doi.org/10.1007/BF00799428
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00799428