Bulletin of Experimental Biology and Medicine

, Volume 83, Issue 2, pp 200–202 | Cite as

Aggregated immunoglobulins on the surface of rapidly dividing antigen-binding lymphocytes

  • A. Ya. Kul'berg
  • D. R. Kaulen
  • V. V. Khorobrykh
  • B. L. Yurin
Microbiology and Immunology


In the primary immune response of mice to sheep's red cells rosette-forming cells with aggregated immunoglobulins on their surface appear in the fraction of small lymphocytes in the spleen. These cells effectively incorporate thymidine and can be eliminated in vivo by injecting the mice with large doses of the tritiated base. It can be concluded from the results that rapidly dividing lymphocytes, specifically binding antigen, characteristically have aggregated immunoglobulins on their surface.

Key Words

rosette-forming cells aggregated immunoglobulins antigen-binding receptors 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • A. Ya. Kul'berg
  • D. R. Kaulen
  • V. V. Khorobrykh
  • B. L. Yurin

There are no affiliations available

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