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Action of serotonin on smooth muscles

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

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Abstract

Serotonin causes contraction of the smooth muscles of the vas deferens and of a strip of stomach from rats by its action on D-serotonin receptors. Only a small part (about 10–14%) of its contractile effect is due to liberation of endogenous catecholamines. The action of serotonin on a strip of rat stomach is accompanied by increased entry of isotropes45Ca and22Na into its cell. The change of direction of the curve of concentration versus effect of serotonin on the strip of stomach is due to accumulation of sodium ions in the cells.

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Authors
  1. I. I. Abramets
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  2. I. V. Komissarov
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  3. I. M. Samoilovich
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  4. V. I. Shovtuta
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Abramets, I.I., Komissarov, I.V., Samoilovich, I.M. et al. Action of serotonin on smooth muscles. Bull Exp Biol Med 83, 174–177 (1977). https://doi.org/10.1007/BF00799414

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  • DOI: https://doi.org/10.1007/BF00799414

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