Abstract
The corticosteroid concentration in the blood of rats was found to be lowered after injection of 3-acetylpyridine. In rats previously given 3-acetylpyridine, ACTH reduced the fall in the corticosteroid level in the blood and adrenal tissue compared with that in intact animals. Glucose-6-phosphate dehydrogenase activity in the adrenals was reduced after administration of 3-acetylpyridine. It is suggested that 3-acetylpyridine exerts its action at the adrenal level by inhibiting NADPH generation in dehydrogenase system.
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Tarasov, Y.A., Strumilo, S.A. & Vinogradov, V.V. Effect of 3-acetylpyridine on adrenocortical function. Bull Exp Biol Med 83, 158–160 (1977). https://doi.org/10.1007/BF00799409
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DOI: https://doi.org/10.1007/BF00799409