Skip to main content
SpringerLink
Log in

Effect of glucocorticoids on α-fetoprotein synthesis and liver structure of mice with acute carbon tetrachloride poisoning

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on male C57BL mice showed that inhalation of CCl4 for 15 min in a concentration of 0.05 ml/4 liters air causes severe degenerative changes in the liver with features of necrobiosis. However, phenomena of regeneration and cell infiltration arise as early as after 24 h and are accompanied by the secretion of α-fetoprotein into the blood stream. After 4 days the foci of necrobiosis disappear and are totally replaced by lymphocytes with large hepatocytes at the periphery. Processes of regeneration in animals receiving hydrocortisone (20 mg/kg) or dexamethasone (2 mg/kg) therapeutically or prophylactically were less marked and the number of animals producing α-fetoprotein was reduced from 92 to 60–65%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. G. I. Abelev, S. D. Perova, et al., Biokhimiya, No. 4, 625 (1963).

    Google Scholar 

  2. R. D. Bakirov, Byull. Éksp. Biol. Med., No. 2, 45 (1968).

    Google Scholar 

  3. F. E. Vishnevetskii and V. N. Masyukevich, in: Current Problems in the Clinical Morphology of Diseases of the Digestive Organs [in Russian], Dnepropetrovsk (1969), p. 59.

  4. L. A. Zarinya, “Investigation of the effectiveness of cyanocobalamin and glucocorticosteroids in infectious hepatitis and acute experimental liver lesions,” Author's Abstract of Candidate's Dissertation, Riga (1968).

  5. A. G. Konyaeva, in: Proceedings of the Sixth Volga Conference of Physiologists with the Participation of Biochemists, Pharmacologists, and Morphologists [in Russian], Vol. 1, Cheboksary (1973), p. 179.

  6. S. D. Perova and G. I. Abelev, Vopr. Med. Khim., No. 4, 369 (1967).

    Google Scholar 

  7. D. S. Sarkisov and L. S. Rubetskoi, Ways of Regeneration of the Cirrhotically Changed Liver [in Russian], Moscow (1965).

  8. Yu. S. Tatarinov, Vopr. Med. Khim., No. 2, 20 (1965).

    Google Scholar 

  9. C. Chera, L. Raileanu, et al., Rev. Roum. Embriol. Cytol., Ser. Cytol.,3, 113 (1966).

    Google Scholar 

  10. O. Ouchterlony, Lancet,1, 346 (1949).

    Google Scholar 

Download references

Authors
  1. A. G. Konyaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. E. Vishnevetskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Konyaeva, A.G., Vishnevetskii, F.E. Effect of glucocorticoids on α-fetoprotein synthesis and liver structure of mice with acute carbon tetrachloride poisoning. Bull Exp Biol Med 83, 146–148 (1977). https://doi.org/10.1007/BF00799405

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00799405

Key Words

Search

Navigation