Abstract
The effect of prostaglandin B1 (PGB1) on the cardiovascular system was studied in experiments on anesthetized dogs. After intravenous injection of PGB1 (40 μg/kg in a single dose) arterial hypotension tachycardia, increased myocardial contractility, an increased cardiac output, and a rise of pressure in the pulmonary artery were observed. The total peripheral resistance and total pulmonary resistance were reduced. The work of the right and left ventricles was increased. The coronary blood flow was increased by 29%. The mean velocity of the volume blood flow in the renal and femoral arteries was appreciably increased after administration of PGB1, but in the common carotid and superior mesenteric arteries the increase was not significant. Changes in the systemic and regional hemodynamics were of short duration.
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Ismailov, S.I., Flerov, E.V. Effect of prostaglandin B1 on the systemic and regional hemodynamics. Bull Exp Biol Med 83, 117–120 (1977). https://doi.org/10.1007/BF00799396
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DOI: https://doi.org/10.1007/BF00799396