Abstract
The histological and ultrastructural changes in the acinar parenchyma of the pancreas produced by the action of ethanol were studied in experiments on Wistar albino rats. Lipid inclusions discovered by the author in the cytoplasm of the acinar cells and changes in the mitochondria were regarded as functional. The opinion of several workers that alcohol has a cytotoxic action on the pancreas is not confirmed by the author. The results of this investigation question the leading role of alcohol in the etiology of acute pancreatitis.
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Literature Cited
N. K. Permyakov, A. E. Padol'skii, and G. P. Titova, Ultrastructural Analysis of the Secretory Cycle of the Pancreas [in Russian], Moscow (1973).
A. A. Shelagurov, Diseases of the Pancreas [in Russian], Moscow (1970).
W. M. Baylis and E. H. Starling, J. Physiol (London),28, 325 (1902).
E. Clark, Am. J. Dig. Dis.,9, 426 (1942).
J. Cueto, N. Tajen, and B. Zimmerman, Surgery.,62, 159 (1967).
N. Darle, R. Ekholm, and J. Edlung, Gastroenterology,58, 62 (1970).
D. A. Dreiling, A. Richman, and N. F. Fradkin, Gastroenterology,20, 636 (1952).
N. Friedreich, in: Cyclopedia of the Practice of Medicine, Vol. 8, New York (1878), p. 601.
H. D. Jonowity and M. Bayer, Ann. Intern. Med.,74, 444 (1971).
E. Lefas, Arch. Gen. Med.,3, 539 (1900).
W. K. Myers and C. S. Keefer, New Engl. J. Med.,210, 376 (1934).
Poggenpohl, cited by D. A. Dreiling et al. [7].
V. M. Sardesai and J. M. Orten, J. Nutr.,96, 241 (1968).
H. Schapiro, L. D. Wruble, and L. G. Britt, Surgery,60, 1108 (1966).
W. Symmons, Dublin J. Med. Sci., No. 143, 244 (1917).
F. Tasso, J. Clop, H. Sarles, et al., Pathol. Biol.,15, 733 (1967).
B. E. Walton, H. Schapiro, and E. D. Woodward, Ann. Surg.,28, 443 (1962).
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Podol'skii, A.E. Effect of ethanol on ultrastructure of the pancreatic acini. Bull Exp Biol Med 83, 436–438 (1977). https://doi.org/10.1007/BF00799387
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DOI: https://doi.org/10.1007/BF00799387