Abstract
The development of experimental silicosis during simultaneous administration of polyvinylpyridine-N-oxide was studied by scanning and transmission electron-microscopic and cytochemical methods. Most macrophages were found to preserve their active function and to phagocytose quartz and to remove it through the air passages. In the fibroblasts the liberation of proteins onto the cell surface was delayed and the intensity of formation of collagen fibers was reduced. Administration of the polymer prevented the development of fibrosis of the lungs.
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Literature Cited
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Arutyunov, V.D., Kruglikov, G.G., Batsura, Y.D. et al. Cytopharmacological effect of polyvinylpyridine-N-oxide in experimental silicosis. Bull Exp Biol Med 83, 429–431 (1977). https://doi.org/10.1007/BF00799385
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DOI: https://doi.org/10.1007/BF00799385