Abstract
After sensitization of guinea pigs with an oily suspension ofBordetella pertussis cells, starting from the 14th day a persistent leukocytosis and lymphocytosis was observed in the peripheral blood of the animals. The leukocytic formula showed a shift to the left. On contact between the blood leukocytes and specific brain antigen bothin vivo andin vitro the leukocytolysis and allergic changes in the leukocytes observed in the late stages of sensitization (in the period of clinical manifestations of experimental allergic encephalomyelitis — EAE) took place mainly at the expense of the granulocytes. These changes are tentatively attributed to antibrain antibodies present in the blood in this period of EAE, i. e., to a combination of allergic reactions of immediate type and reactions of delayed type in a common mechanism of development of pertussis EAE.
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Kanchurin, A.K., Babakhin, A.A. & Safronova, A.V. Role of allergic reactions of peripheral blood leukocytes in the pathogenesis of experimental allergic (pertussis) encephalomyelitis. Bull Exp Biol Med 83, 366–369 (1977). https://doi.org/10.1007/BF00799365
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DOI: https://doi.org/10.1007/BF00799365