Skip to main content
SpringerLink
Log in

Effect of somatotropic hormone on autoimmune responses induced in mice of various genotypes by heated syngeneic erythrocytes

  • Microbiology and Imnunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After a single injection of 1·109 heated syngeneic erythrocytes into BALB/c and C57BL mice, antierythrocytic autoantibodies appear, the weight of the lymphoid organs is increased, and lymphoid-reticular hyperplasia is observed on the 13th day. These changes are more marked in BALB/c mice. During the development of the autoimmune response changes occurred in the number of E- and EAC-rosette-forming cells in the thymus and spleen and in the intensity of the response to immunization by sheep's red cells andEscherichia coli endotoxin, when distinct differences were observed between the strains. Injection of somatotropic hormone in a dose of 5 mg/kg daily for 10 days reduced the degree of development of the autoimmune response in mice of both strains, but more strongly in BALB/c mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. F. Burnet, Cellular Immunology, Cambridge Univ. Press, New York (1969).

    Google Scholar 

  2. I. M. Lyampert, Usp. Sovrem. Biol., No. 2, 274 (1976).

    Google Scholar 

  3. V. A. Trufakin, V. G. Dudin, and T. P. Noppe, Abstracts of Proceedings of the Eighth All-Union Congress of Anatomists, Histologists, and Embryologists [in Russian], Tashkent (1974), p. 380.

  4. A. C. Allison, in: Contemporary Topics in Immunology, Vol. 3, New York (1974), pp. 227–242.

  5. A. Arnaiz-Villena, J. H. L. Playfair, and I. M. Roitr, Clin. Exp. Immunol.,20, 375 (1975).

    Google Scholar 

  6. S. Arrenbrecht and E. Sorkin, Eur. J. Immunol.,3, 601 (1973).

    Google Scholar 

  7. P. J. Baker, Transplant. Rev.,26, 3 (1975).

    Google Scholar 

  8. A. J. Cunningham, Nature,207, 1106 (1965).

    Google Scholar 

  9. B. Halpern and G. Bourdon, C. R. Acad. Sci. (Paris),273D, 2712 (1971).

    Google Scholar 

  10. Y. Namba and B. A. Waksman, Exp. Cell Res.,94, 23 (1975).

    Google Scholar 

  11. L. C. Norins and M. C. Holmes, J. Immunol.,93, 897 (1964).

    Google Scholar 

  12. A. D. Steinberg, Arthr. Rheum.,17, 11 (1974).

    Google Scholar 

  13. L. Stockinger and G. Kellner, Wien. Z. Inn. Med.,33, 135 (1952).

    Google Scholar 

  14. O. B. Zaalberg, Nature,202, 1231 (1964).

    Google Scholar 

Download references

Authors
  1. V. A. Trufakin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. P. Lozovoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. P. Noppe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Robinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. N. Chigir'
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trufakin, V.A., Lozovoi, V.P., Noppe, T.P. et al. Effect of somatotropic hormone on autoimmune responses induced in mice of various genotypes by heated syngeneic erythrocytes. Bull Exp Biol Med 83, 348–351 (1977). https://doi.org/10.1007/BF00799359

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00799359

Key Words

Search

Navigation