Abstract
The effect of chloramphenicol (CA) and dextramycin (DM) on the adrenocorticolytic action of 7,12-dimethylbenz(a)anthracene (DMBA) was studied in rats. Administration of CA in doses of 0.1–1.0 mg/g and of DM in doses of 0.05–1.0 mg/g 1.5 h before the carcinogen was shown to prevent the development of adrenal necrosis completely. If smaller doses of CA and DM were given, and also if they were given 48 h before the carcinogen or 1.5 h after it, the protective effect was partially preserved. If CA and DM were given 3, 6, or 24 h after DMBA the toxic action of the carcinogen was unchanged.
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Bogush, T.A., Konopleva, I.A. Protective effect of chloramphenicol and dextramycin against the adrenocorticolytic action of 7,12-dimethylbenz(a)anthracene. Bull Exp Biol Med 83, 335–337 (1977). https://doi.org/10.1007/BF00799354
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DOI: https://doi.org/10.1007/BF00799354