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Effect of chronic stimulation of rats with intact and deafferented hyplthalami on lipid metabolism and the adrenal cortex

  • Biochemistry and Biophysics
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Bulletin of Experimental Biology and Medicine Aims and scope

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Abstract

Chronic stimulation of rats after a mock operation and rats with deafferented hypothalami leads to a decrease in the total cholesterol concentration in the blood and to the accumulation of triglycerides in the liver. Injection of dexamethasone into rats is accompanied by an increase in the blood cholesterol and triglyceride concentrations and accumulation of triglycerides in the liver. The action of dexamethasone is stronger in animals with a deafferented hypothalamus. The rate of secretion of 11-hydroxycorticosteroids into the adrenal vein was reduced in the latter.

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Literature Cited

  1. M. L. Belen'kii, Elements of Quantitative Evaluation of a Pharmacological Effect [in Russian], Leningrad (1963).

  2. Yu. N. Bordyushkov and L. Kh. Garkavi, Byull. Éksp. Biol. Med., No. 6, 61 (1963).

    Google Scholar 

  3. E. N. Gerasimova, in: Structure, Biosynthesis, and Conversion of Lipidsin vivo in Animals and Man [in Russian], Moscow (1975), p. 7.

  4. V. E. Ryzhenkov, T. A. Oletskaya, and N. S. Sapronov, Byull. Éksp. Biol. Med., No. 3, 50 (1973).

    Google Scholar 

  5. I. Ya. Usvatova and Yu. A. Pankov, in: Modern Methods in Determining Steroid Hormones in Biological Fluids [in Russian], Moscow (1968), p. 39.

  6. G. G. Khechinashvili, in: The Pharmacological Regulation of Metabolic Processes (ed. by P. O. Denisenko) [in Russian], Leningrad (1972), p. 109.

  7. D. Atanacković, P. Dimnik, J. Erčič, et al., Atca Pharm. Iugosl.,24, 143 (1974).

    Google Scholar 

  8. G. H. Bragdon, in: Lipids and the Steroid Hormones in Clinical Medicine, Philadelphia (1960), p. 6.

  9. B. Halasz and L. Pupp, Endocrinology,77, 533 (1965).

    Google Scholar 

  10. K. Itaya and M. Ui, J. Lipid Res.,6, 16 (1965).

    Google Scholar 

  11. B. P. Neri and C. S. Frings, Clin. Chem.,19, 1201 (1973).

    Google Scholar 

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Authors
  1. V. E. Ryzhenkov
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  2. N. S. Sapronov
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  3. G. G. Khechinashvili
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  4. I. V. Mosina
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  5. T. A. Oletskaya
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Ryzhenkov, V.E., Sapronov, N.S., Khechinashvili, G.G. et al. Effect of chronic stimulation of rats with intact and deafferented hyplthalami on lipid metabolism and the adrenal cortex. Bull Exp Biol Med 83, 326–328 (1977). https://doi.org/10.1007/BF00799351

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  • DOI: https://doi.org/10.1007/BF00799351

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