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Role of adrenergic structures of the CNS in changes in function of the hypothalamic-pituitary-adrenal system during exogenous hyperthermia

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Subcutaneous injection of chlorpromazine into rats leads to a smaller rise of body temperature and a higher concentration of corticotropin-releasing factor in the hypothalamus and of ACTH in the pituitary during exogenous hyperthermia. The ascorbic acid concentration in the adrenals falls just as in hyperthermic animals without chlorpromazine. The weight of the adrenal is not significantly changed. It is concluded that central adrenergic structures play a part in the regulation of the synthesis or secretion of corticotropin-releasing factor.

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Authors
  1. I. A. Degonskii
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Degonskii, I.A. Role of adrenergic structures of the CNS in changes in function of the hypothalamic-pituitary-adrenal system during exogenous hyperthermia. Bull Exp Biol Med 83, 293–295 (1977). https://doi.org/10.1007/BF00799340

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  • DOI: https://doi.org/10.1007/BF00799340

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