Advertisement

Oxidative phosphorylation in the skeletal muscles of rabbits during dinitrophenol hyperthermia

  • M. A. Shvets
Biochemistry and Biophysics
  • 32 Downloads

Abstract

After intramuscular injection of 2,4-dinitrophenol (DNP) into rabbits in doses of 10, 15, 25, and 30 mg/kg the degree of elevation of the body temperature, the increase in the oxygen consumption, and the degree of uncoupling of oxidative phosphorylation in skeletal muscle homogenates were found to increase with the dose. In the course of dinitrophenol hyperthermia (following injection of 25 mg/kg DNP) the changes in body temperature and oxygen consumption of the animals followed a parallel course with the changes in the level of oxidative phosphorylation in the skeletal muscles.

Key Words

dinitrophenol hyperthermia oxidative phosphorylation rabbit skeletal muscles oxygen consumption 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    O. N. Burats'ka and I. O. Anina, Ukr. Biokhim. Zh., No. 5 576 (1969).Google Scholar
  2. 2.
    P. N. Veselkin, Fiziol. Zh. SSSR,41, 108 (1955).Google Scholar
  3. 3.
    G. M. Daudova and M. A. Shvets, Biokhimiya,38, No. 2, 304 (1973).Google Scholar
  4. 4.
    V. I. Zhivkov, Kh. Chembonova-Lorer, and V. N. Ponaionov, Biokhimiya, No. 3, 484 (1970).Google Scholar
  5. 5.
    V. P. Skulachev, The Accumulation of Energy in the Cell [in Russian], Moscow (1969).Google Scholar
  6. 6.
    M. A. Shvets, Biokhimiya,36, No. 2, 244 (1971).Google Scholar
  7. 7.
    T. M. Brody and J. A. Bain, J. Pharmacol. Exp. Ther.,110, 148 (1954).Google Scholar
  8. 8.
    M. U. Dianzani, Biochim. Biophys. Acta,44, 13 (1960).Google Scholar
  9. 9.
    H. A. Lardy and C. A. Elvehjem, Ann. Rev. Biochem.,14, 1 (1945).Google Scholar
  10. 10.
    W. F. Loomis and F. Lipman, J. Biol. Chem.,173, 807 (1948).Google Scholar
  11. 11.
    W. H. Parker, Nature178, 261 (1956).Google Scholar
  12. 12.
    S. H. Fiske and V. J. Subbarow, J. Biol. Chem.,66, 375 (1925).Google Scholar
  13. 13.
    M. L. Tainter and W. C. Cutting, J. Pharmacol. Exp. Ther.,48, 410 (1933).Google Scholar

Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1974

Authors and Affiliations

  • M. A. Shvets

There are no affiliations available

Personalised recommendations