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Analysis of analgesia evoked by creation of an excitation generator in dorsal raphe nucleus

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

An excitation generator was created in the dorsal raphe nucleus of the mesencephalon in experiments on albino rats by microinjection of tetanus toxin into the nucleus. During formation of the excitation generator electrical activity was found to change in this nucleus, with a sharp increase in the primary negative component (N1) and a change in the general configuration of the evoked potentials (EP), and an increase in the frequency of spontaneous paroxysmal activity. These changes in EP coincide in time with the appearance of deep and increasing analgesia. The type of analgesia described is not abolished by naloxone.

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Literature Cited

  1. S. I. Igon'kina and G. N. Kryzhanovskii, Byull. Éksp. Biol. Med., No. 7, 16 (1977).

    Google Scholar 

  2. G. N. Kryzhanovskii, Zh. Nevropatol. Psikhiatr.,76, 1090 (1976).

    Google Scholar 

  3. G. N. Kryzhanovskii, Zh. Nevropatol. Psikhiatr.,76, 1730 (1976).

    Google Scholar 

  4. G. N. Kryzhanovskii and S. I. Igon'kina, Byull. Éksp. Biol. Med., No. 2, 145 (1978).

    Google Scholar 

  5. Yu. S. Sverdlov, Neirofiziologiya, No. 1, 25 (1969).

    Google Scholar 

  6. V. B. Brooks, D. P. Curtis, and J. C. Eccles, J. Physiol. (London),136, 655 (1957).

    Google Scholar 

  7. D. P. Curtis, D. Felix, C. J. A. Gane, et al., Brain Res.,51, 358 (1973).

    Google Scholar 

  8. H. W. Kosterlitz and J. Hughs, in: Advances in Pain Research and Therapy, Vol. 1, New York (1976). p. 641.

  9. F. D. Olson, D. A. Twombly, and J. C. Liebeskind, Pain,4, 2139 (1978).

    Google Scholar 

  10. J. L. Oliveras, F. Redjemi, G. Guilbaud, et al., Pain,1, 139 (1975).

    Google Scholar 

  11. D. J. Mayer and J. C. Liebeskind, Brain Res.,68, 73 (1974).

    Google Scholar 

  12. L. J. Pellegrino and A. J. Cushman, A Stereotaxic Atlas of the Rat Brain, Plenum Press, New York (1967).

    Google Scholar 

  13. B. Pomeranz, R. Cheng, and P. Law, Exp. Neurol.,54, 172 (1977).

    Google Scholar 

  14. T. L. Yaksh, J. C. Yeung, and T. A. Rudy, Brain Res.,114, 83 (1976).

    Google Scholar 

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Igon'kina, S.I., Kryzhanovskii, G.N. Analysis of analgesia evoked by creation of an excitation generator in dorsal raphe nucleus. Bull Exp Biol Med 88, 978–981 (1979). https://doi.org/10.1007/BF00799258

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  • DOI: https://doi.org/10.1007/BF00799258

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