Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 3, pp 978–981 | Cite as

Analysis of analgesia evoked by creation of an excitation generator in dorsal raphe nucleus

  • S. I. Igon'kina
  • G. N. Kryzhanovskii
Pathological Physiology and General Pathology


An excitation generator was created in the dorsal raphe nucleus of the mesencephalon in experiments on albino rats by microinjection of tetanus toxin into the nucleus. During formation of the excitation generator electrical activity was found to change in this nucleus, with a sharp increase in the primary negative component (N1) and a change in the general configuration of the evoked potentials (EP), and an increase in the frequency of spontaneous paroxysmal activity. These changes in EP coincide in time with the appearance of deep and increasing analgesia. The type of analgesia described is not abolished by naloxone.

Key Words

Analgesia excitation generator tetanus toxin evoked potentials dorsal raphe nucleus 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • S. I. Igon'kina
  • G. N. Kryzhanovskii
    • 1
  1. 1.Academy of Medical Sciences of the USSRUSSR

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