Abstract
Hypertrophy of the myocardium was induced in rats and mice by training in a pressure chamber or ligation of the apex of the heart. Two weeks later the formation of transversely oriented myofibrils was observed beneath the sarcolemma in some of the ventricular myocardiocytes. It is suggested that this phenomenon depends on the development of transverse mechanical forces beneath the sarcolemma as a result of an increase in volume of the cells.
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Eriskovskaya, N.K., Tsellarius, Y.G. Formation of transversely oriented myofibrils in myocardiocytes of the hypertrophied heart. Bull Exp Biol Med 83, 899–901 (1977). https://doi.org/10.1007/BF00798911
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DOI: https://doi.org/10.1007/BF00798911