Brain nucleic acid content of inbred rats of various strains

  • K. B. Nazaryan
  • I. I. Mitrofanov
  • V. V. Sal'nikov
Morphology and Pathomorphology


Changes in the nucleic acid content were studied during defensive conditioning to electric shocks. In WAG rats a reflex was formed on average after 42.7 presentations of combined electrical and photic stimulation, compared with 14.09 combinations in August rats. Cytophotometric determination of the nucleic acid content in the neurons and perineuronal glia of the cortex revealed an increase in RNA only in August rats. It is suggested that the increased RNA synthesis in the animals of this strain may be the material basis of their greater ability to learn.

Key words

inbred animals defensive conditioning nucleic acids neurons 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Yu. Ya. Geinisman, Structural and Metabolic Manifestations of Neuron Function [in Russian], Moscow (1974).Google Scholar
  2. 2.
    Yu. Ya. Geinisman, V. N. Larina, E. V. Maksimov, et al., Dokl. Akad. Nauk SSSR,202 1225 (1972).Google Scholar
  3. 3.
    L. Z. Pevzner, Dokl. Akad. Nauk SSSR,156, 1213 (1964).Google Scholar
  4. 4.
    L. Z. Pevzner, Tsitologiya, No. 9, 840 (1967).Google Scholar
  5. 5.
    D. Bovet, F. Bovet-Nitti, and A. Oliverio Science,163, 139 (1969).Google Scholar
  6. 6.
    R. D. Ciarnello, R. Barchas, S. Kessler, et al., Life Sci.,11, 565 (1972).Google Scholar
  7. 7.
    Z. Cohen, Physiol. Rev.,53, 373 (1973).Google Scholar
  8. 8.
    H. Hyden, Proc. Nat. Acad. Sci. USA,52, 1415 (1964).Google Scholar
  9. 9.
    J. Jarlsted Acta Physiol Scand.,67, 243 (1967).Google Scholar
  10. 10.
    J. Marx, Science,178, 1188 (1972).Google Scholar
  11. 11.
    D. McAfee, Science,171, 1156 (1971).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • K. B. Nazaryan
  • I. I. Mitrofanov
  • V. V. Sal'nikov

There are no affiliations available

Personalised recommendations