Brain nucleic acid content of inbred rats of various strains
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Changes in the nucleic acid content were studied during defensive conditioning to electric shocks. In WAG rats a reflex was formed on average after 42.7 presentations of combined electrical and photic stimulation, compared with 14.09 combinations in August rats. Cytophotometric determination of the nucleic acid content in the neurons and perineuronal glia of the cortex revealed an increase in RNA only in August rats. It is suggested that the increased RNA synthesis in the animals of this strain may be the material basis of their greater ability to learn.
Key wordsinbred animals defensive conditioning nucleic acids neurons
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