Abstract
Ontogenetic changes in normal diploid cells and cells with chromosomal aberrations (strain LTsCh-162;47,XY, +7) during long-term culture in the stationary phase were studied. The human fibroblasts in culture were found to possess a type of ontogenetic change specific for each culture, and the dynamics of these changes depended on the density of the cell population. Two morphologically different subpopulations of cells, differing in their degree of heterochromatinization of the cell nucleus (under normal conditions), and three different subpopulations of cells in the aberrant strain (47,XY, +7) were found on investigation of the cell nucleus.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
S. G. Vorsanova, K. N. Grinberg, T. L. Éraizer, et al., Arkh. Anat., No. 11, 74 (1975).
F. E. Arrighi and T. C. Hsu, Cytogenetics,10, 81 (1971).
A. M. Kuliev et al., Humangenetik,17, 285 (1973).
Rights and permissions
About this article
Cite this article
Vorsanova, S.G. Dynamics of changes in abnormal human cells during long-term culture in the stationary phase investigation of cells with trisomy 7. Bull Exp Biol Med 83, 884–886 (1977). https://doi.org/10.1007/BF00798906
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00798906